B.L.O.O.M. drive

If you need a lot of power for a long time, Nuke is the way to go, it's a bit dirty and there's a margin of error and not much of a way to fix a "flat" so to speak.
But you line that sucker up and put a shield between you and the loud part, you can go fast and longer than almost any other type of propulsion you can think of.
Of course you should only do that half of the way there - Silly thing like physics will want you to be spending the other half of your time slowing the beast down. to do that all you have to do is turn around.
Ever try to do a handbrake turn with a nuclear reaction going on in the trunk?